CATH Domain 5gn6D01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.40	ATPase, nucleotide binding domain

Domain Context

CATH Clusters

Superfamily	3.30.420.40
Functional Family	Glycerol kinase

Enzyme Information

2.7.1.30

Glycerol kinase.

based on mapping to UniProt D3KVM3

ATP + glycerol = ADP + sn-glycerol 3-phosphate.

-!- Glycerone and L-glyceraldehyde can act as acceptors. -!- UTP (and, in the case of the Saccharomyces cerevisiae enzyme, ITP and GTP) can act as donors.

UniProtKB Entries (1)

D3KVM3

D3KVM3_TRYBG

Trypanosoma brucei gambiense

Glycerol kinase

PDB Structure

PDB	5GN6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase ofTrypanosoma brucei brucei. Balogun, E.O., Inaoka, D.K., Shiba, T., Tsuge, C., May, B., Sato, T., Kido, Y., Nara, T., Aoki, T., Honma, T., Tanaka, A., Inoue, M., Matsuoka, S., Michels, P.A.M., Watanabe, Y.I., Moore, A.L., Harada, S., Kita, K. Faseb J.