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CATH Superfamily 2.40.10.10

Trypsin-like serine proteases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Trypsin-like serine proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 46619: Complement factor D (Adipsin)

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Trypsin. [EC: 3.4.21.4]
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.4.4.
 16 A0A076LZC5 A0A076LZC5 A0A1D8QLQ0 A0A1D8QLQ0 A0A1D8QLQ2 A0A1D8QLQ2 B7P540 B7P540 E9GTT1 E9GTT1
(6 more...)
Complement factor D. [EC: 3.4.21.46]
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
  • A component of the alternative pathway of complement activation.
  • This reaction is analogous to the activation of complement component C2 by activated complement subcomponent C1s.
  • Belongs to peptidase family S1.
 14 A0A061I2Z8 A0A061I2Z8 P00746 P00746 P03953 P03953 P32038 P32038 P51779 P51779
(4 more...)
Granzyme A. [EC: 3.4.21.78]
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- >> -Phe-|-Xaa- in small molecule substrates.
  • From cytotoxic T lymphocyte granules.
  • The human enzyme does not cleave Phe-|-Xaa.
  • Belongs to peptidase family S1.
 10 L8J1B0 L8J1B0 P11032 P11032 P12544 P12544 Q3U0N0 Q3U0N0 Q7YRZ7 Q7YRZ7
Chymotrypsin. [EC: 3.4.21.1]
Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.4.5 and EC 3.4.4.6.
 4 A0A059WNI1 A0A059WNI1 A0A1B2LPB9 A0A1B2LPB9
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