The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Trypsin-like serine proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 46604: Mast cell protease 2

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Chymase. [EC: 3.4.21.39]
Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.
  • In mast cell granules.
  • Belongs to peptidase family S1.
22 A0A061IG37 A0A061IG37 A0A061IH44 A0A061IH44 A7WPL7 A7WPL7 P09650 P09650 P21842 P21842
(12 more...)
Granzyme B. [EC: 3.4.21.79]
Preferential cleavage: -Asp-|-Xaa- >> -Asn-|-Xaa- > -Met-|-Xaa-, -Ser-|-Xaa-.
  • From cytotoxic T lymphocyte granules.
  • Belongs to peptidase family S1.
8 P04187 P04187 P10144 P10144 P18291 P18291 Q3TZH4 Q3TZH4
Cathepsin G. [EC: 3.4.21.20]
Specificity similar to chymotrypsin C.
  • From azurophil granules of polymorphonuclear leukocytes.
  • Belongs to peptidase family S1.
8 A0A061IJ91 A0A061IJ91 P08311 P08311 P28293 P28293 Q059V7 Q059V7
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