View in Gene3D

CATH Superfamily 2.40.10.10

Trypsin-like serine proteases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Trypsin-like serine proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 46292: Chymotrypsin-like elastase family member 2A

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pancreatic elastase II. [EC: 3.4.21.71]
Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa. Hydrolyzes elastin.
  • Formed by activation of proelastase II from mammalian pancreas by trypsin.
  • Usually, only one of the pancreatic elastases (see also EC 3.4.21.36) is expressed in a given species; human pancreatic elastase is of type II.
  • Belongs to peptidase family S1.
 14 E3TE32 E3TE32 P00774 P00774 P05208 P05208 P08217 P08217 P08218 P08218
(4 more...)
Chymotrypsin C. [EC: 3.4.21.2]
Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.
  • Reacts more readily with Tos-Leu-CH(2)Cl than Tos-Phe-CH(2)Cl, in contrast to chymotrypsin.
  • Belongs to peptidase family S1.
 12 A0A061IEE2 A0A061IEE2 B0JYP7 B0JYP7 P55091 P55091 Q3SYP2 Q3SYP2 Q7M3E1 Q7M3E1
(2 more...)
Pancreatic endopeptidase E. [EC: 3.4.21.70]
Preferential cleavage: Ala-|-Xaa. Does not hydrolyze elastin.
  • From pancreatic juice.
  • Unlike elastases, has an acidic pI.
  • Binds cholesterol.
  • Belongs to peptidase family S1.
 8 O19023 O19023 P08861 P08861 P09093 P09093 Q9CQ52 Q9CQ52
Pancreatic elastase. [EC: 3.4.21.36]
Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa.
  • Formed by activation of proelastase from mammalian pancreas by trypsin.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.4.7 and EC 3.4.21.11.
 2 Q7SIG3 Q7SIG3
Leukocyte elastase. [EC: 3.4.21.37]
Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.
  • Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.4.7 and EC 3.4.21.11.
 2 Q92077 Q92077
CATH-Gene3D is a Global Biodata Core Resource Learn more...