The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Trypsin-like serine proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3834: Transmembrane protease serine 9

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Trypsin. [EC: 3.4.21.4]
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.4.4.
54 A0A0F0B8D0 A0A0F0B8D0 A0A0H3AGH4 A0A0H3AGH4 A0A0K2B040 A0A0K2B040 A0A0K9UUZ4 A0A0K9UUZ4 A0A0N1FL20 A0A0N1FL20
(44 more...)
Chymotrypsin. [EC: 3.4.21.1]
Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.4.5 and EC 3.4.4.6.
4 P00766 P00766 P47796 P47796
Plasma kallikrein. [EC: 3.4.21.34]
Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.
  • Formed from plasma prokallikrein (Fletcher factor) by factor XIIa.
  • Activates coagulation factors XII, VII and plasminogen.
  • Selective for Arg > Lys in P1, in small molecule substrates.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.4.21 and EC 3.4.21.8.
2 B7PAT9 B7PAT9
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